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Gynaecologia et perinatologia : journal for gynaecology, perinatology, reproductive medicine and ultrasonic diagnostics, Vol. 13 No. 4, 2004.

Original scientific paper

ANALYSIS OF PROGNOSTIC FACTORS AND OF TYPE OF TREATMENT IN PATIENTS WITH ENDOMETRIAL CANCER IN THE FIRST FIGO STAGE

Herman Haller
Maja Kraševic
Teodora Stanković
Drazen Kovač
Ružica Karnjuš-Begonja
Stanislav Rupčić
Ozren Mamula
Darko Mozetič
Miroslav Stamatović
Miljenko Manestar
Alenka Brnčić-Fisher
Nebojša Sindik

Full text: croatian pdf 146 Kb

page 149-154

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Abstract

Objective. To analyze the effect of histopathologic characteristics and usefullness of therapy mode in FIGO stage I endometrial cancer patients. Methods. Retrospectively were analyzed 219 endometrial cancer patients with hysterectomy, salpingoophorectomy and pelvic lymphadenectomy (peritoneal cytology and nodes negative). Patients characteristics include age, myometrial invasion, FIGO substages, histologic type, tumor grade, type of hysterectomy and adjuvant radio¬therapy. The mean age was 59 years (SD 8, Min. 39, Max. 75 years). Follow up ranges from 1 to 180 months (median 68). In 85 patients radical hysterectomies were performed and 45 patients received adjuvant radiotherapy. Results. Five year disease related survival was 92,8%. There is no significant difference among analyzed histopathologic patient’s characteristics related to five years survival. In 82 (37.3%) patients out of 219 were found cumulative negative prognostic factors (high risk patients) including non-endometrioid histology, poor tumor differentiation and/or outer half of miometrial invasion. There is no difference in survival between low (91,2%) and high risk patients (93,9%). Radical hysterectomy as well as adjuvant radiotherapy has no advantage in five year survival. Conclusion. This retrospective study has not identified histopathologic prognostic significant characteristics in FIGO stage I endometrial cancer patients. The use of radical hysterectomy and/or adjuvant radiotherapy has not better five years survival and should be reevaluated.

Keywords

endometrial cancer; FIGO; adjuvant therapy; lymphadenectomy; myometrial invasion; tumor differentiation; histology

Hrčak ID:

15597

URI

https://hrcak.srce.hr/15597

Publication date:

1.12.2004.

Article data in other languages: croatian

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