Original scientific paper

https://doi.org/10.1515/acph-2016-0042

Ionophore-based potentiometric PVC membrane sensors for determination of phenobarbitone in its pharmaceutical formulations

HAITHAM ALRABIAH ; Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, P.O.Box 2457, Riyadh11451, Saudi Arabia
ABDULRAHMAN AL-MAJED ; Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, P.O.Box 2457, Riyadh11451, Saudi Arabia
MOHAMMED ABOUNASSIF ; Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, P.O.Box 2457, Riyadh11451, Saudi Arabia
GAMAL A. E. MOSTAFA ; Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, P.O.Box 2457, Riyadh11451, Saudi Arabia; Micro-Analytical Laboratory, Applied Organic Chemistry Department, National Research Center, Doki, Cairo, Egypt

Abstract

The fabrication and development of two polyvinyl chloride (PVC) membrane sensors for assaying phenobarbitone sodium are described. Sensors 1 and 2 were fabricated utilizing - or -cyclodextrin as ionophore in the presence of tridodecylmethylammonium chloride as a membrane additive, and PVC and dioctyl phthalate as plasticizer. The analytical parameters of both sensors were evaluated according to the IUPAC guidelines. The proposed sensors showed rapid, stable anionic response (–59.1 and –62.0 mV per decade) over a relatively wide phenobarbitone concentration range (5.0×10–6–1×10–2 and 8×10–6–1×10–2 mol L–1) in the pH range of 9–11. The limit of detection was 3.5×10–6 and 7.0×10–6 mol L–1 for sensors 1 and 2, respectively. The fabricated sensors showed high selectivity for phenobarbitone over the investigated foreign species. An average recovery of 2.54 µg mL–1 phenobarbitone sodium was 97.4 and 101.1 %, while the mean relative standard deviation was 3.0 and 2.1 %, for sensors 1 and 2, respectively. The results acquired for determination of phenobarbitone in its dosage forms utilizing the proposed sensors are in good agreement with those obtained by the British Pharmacopoeial method.

Keywords

phenobarbitone sodium; membrane selective electrode; -cyclodextrin, -cyclodextrin; PVC; potentiometry

Hrčak ID:

161194

URI

https://hrcak.srce.hr/161194

Publication date:

31.12.2016.

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