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Journal of Circulating Biomarkers, Vol. 4 No. Godište 2015, 2015.

Review article

https://doi.org/10.5772/61186

Exosomes: Mechanisms of Uptake

Kelly J. McKelvey ; Division of Perinatal Medicine, Kolling Institute of Medical Research, University of Sydney at Royal North Shore Hospital, St Leonards, NSW, Australia
Katie L. Powell ; Division of Perinatal Medicine, Kolling Institute of Medical Research, University of Sydney at Royal North Shore Hospital, St Leonards, NSW, Australia; Pathology North, NSW Health Pathology at Royal North Shore Hospital, St Leonards, NSW, Australia
Anthony W. Ashton ; Division of Perinatal Medicine, Kolling Institute of Medical Research, University of Sydney at Royal North Shore Hospital, St Leonards, NSW, Australia
Jonathan M. Morris ; Division of Perinatal Medicine, Kolling Institute of Medical Research, University of Sydney at Royal North Shore Hospital, St Leonards, NSW, Australia; Department of Obstetrics and Gynaecology, Royal North Shore Hospital, St Leonards, NSW, Australia
Sharon A. McCracken ; Division of Perinatal Medicine, Kolling Institute of Medical Research, University of Sydney at Royal North Shore Hospital, St Leonards, NSW, Australia

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Abstract

Exosomes are 30–100 nm microvesicles which contain complex cellular signals of RNA, protein and lipids. Because of this, exosomes are implicated as having limitless therapeutic potential for the treatment of cancer, pregnancy complications, infections, and autoimmune diseases. To date we know a considerable amount about exosome biogenesis and secretion, but there is a paucity of data regarding the uptake of exosomes by immune and non-immune cell types (e.g., cancer cells) and the internal signalling pathways by which these exosomes elicit a cellular response. Answering these questions is of paramount importance.

Keywords

Exosome; immunology; endocytosis

Hrčak ID:

161446

URI

https://hrcak.srce.hr/161446

Publication date:

1.1.2015.

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