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Psychiatria Danubina, Vol. 26 No. 2, 2014.

Original scientific paper

LEPTIN -2548G/A GENE POLYMORPHISM IN ASSOCIATION WITH ANTIPSYCHOTIC-INDUCED WEIGHT GAIN: A META-ANALYSIS STUDY

Jizhong Shen ; Department of Pharmacy, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, China
Weihong Ge ; Department of Pharmacy, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, China
Jinping Zhang ; Department of Pharmacy, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, China
Huai Jun Zhu ; Department of Pharmacy, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, China
Yun Fang ; Department of Pharmacy, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, China

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Abstract

Background: The leptin -2548G/A (rs7799039) gene polymorphism has been implicated in susceptibility to antipsychoticinduced
weight gain (AIWG), but study results are still controversial. The present meta-analysis was performed to investigate the
relationship between the leptin -2548G/A gene polymorphism and AIWG.
Methods: Electronic databases were searched for eligible articles in English and Chinese and seven separate studies on the
association of the leptin -2548G/A gene polymorphism with AIWG were analyzed.
Results: The meta-analysis involved 451 AIWG patients and 568 controls. The pooled odds ratio (OR) and their corresponding
95% confidence interval (CI) were calculated by a fixed or random effect. Overall, our meta-analysis suggests that the leptin -
2548G/A gene polymorphism was not significantly associated with AIWG risk under various genetic models. But, in the subgroup
analysis by ethnicity, significant association was found between leptin -2548A allele and the AIWG risk in Asian populations under
additive, dominant, recessive, and homozygote genetic model. On the contrary, in European populations, the -2548A allele seemed to
decrease the risk of AIWG when compared with the -2548G allele under various genetic models, even though they were not
statistically significant.
Conclusion: Our meta-analysis suggests that the correlation between leptin -2548G/A gene polymorphism and AIWG risk has
significant racial differences.

Keywords

psychosis - schizophrenia - rs7799039 – genetics - AIWG - meta-analysis

Hrčak ID:

162065

URI

https://hrcak.srce.hr/162065

Publication date:

17.6.2014.

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