Short communication, Note

Acute toxicity of carbaryl and propoxur in mice previously treated with phenobarbiton and SKF 525-A

N. Nešković ; Zavod za pesticide INEP, Zemun, Institut za farmakologiju i toksikologiju Medicinskog fakulteta, Beograd i Katedra za pesticide Poljoprivrednog fakulteta, Zemun
M. Terzić ; Zavod za pesticide INEP, Zemun, Institut za farmakologiju i toksikologiju Medicinskog fakulteta, Beograd i Katedra za pesticide Poljoprivrednog fakulteta, Zemun
S. Vitorović ; Zavod za pesticide INEP, Zemun, Institut za farmakologiju i toksikologiju Medicinskog fakulteta, Beograd i Katedra za pesticide Poljoprivrednog fakulteta, Zemun

Abstract

Acute toxicity of the insecticides carbaryl and propoxur was examined in mice of both sexes by intraperitoneal and subcutaneous administration. The effect of phenobarbiton and SKF 525-A on intraperitoneal toxicity of these insecticides was also studied. Phenobarbiton (60 µg/kg) was administered intraperitoneally 24 hours before carbaryl or propoxur, and SKF 525-A (50 µg/kg) was also given intraperitoneally one hour before carbaryl or propoxur. The results showed a higher toxicity of carbaryl and propoxur after intraperitoneal than after subcutaneous administration, as well as a considerably higher toxicity in male than in female mice. It was also established that phenobarbiton administered 24 hours before carbaryl and propoxur decreases the acute intraperitoneal toxicity of both examined compounds, while SKF 525-A given one hour before carbaryl and propoxur increases their acute intraperitoneal toxicity.

Keywords

Hrčak ID:

162120

URI

https://hrcak.srce.hr/162120

Publication date:

18.12.1978.

Article data in other languages: serbian

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