Psychiatria Danubina, Vol. 26 No. 3, 2014.
Original scientific paper
METABOLIC SYNDROME AND INFLAMMATION MARKERS IN PATIENTS WITH SCHIZOPHRENIA AND RECURRENT DEPRESSIVE DISORDER
Davor Lasić
orcid.org/0000-0001-7571-0291
; Department of Psychiatry, University Hospital Centre Split, Split, Croatia
Milenko Bevanda
; Department of Internal Medicine, University of Mostar School of Medicine, Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
Nada Bošnjak
; Department of Medical Laboratory Diagnosis, University Hospital Centre Split, Split, Croatia
Boran Uglešić
; Department of Psychiatry, University Hospital Centre Split, Split, Croatia
Trpimir Glavina
; Department of Psychiatry, University Hospital Centre Split, Split, Croatia
Tomislav Franić
; Department of Psychiatry, University Hospital Centre Split, Split, Croatia
Abstract
Background: The high prevalence of metabolic syndrome in patients with psychiatric disorders, almost double the prevalence
reported for the general population, is worrying. The aim of this study is to investigate the presence of metabolic syndrome and
inflammatory marker levels in patients with schizophrenia and recurrent depressive disorder in a Croatian psychiatric sample.
Subjects and methods: This study included 62 inpatients with schizophrenia and 62 with recurrent depressive disorder treated at
the Department of Psychiatry, University Hospital Centre Split, enrolled from November 2011 until May 2012. The cases were
compared to 124 healthy subjects from the general population.
Results: The presence of metabolic syndrome was found in 56.5% of the patients with schizophrenia and 53.2% of the patients
with depression, which was significantly more prevalent than in the control group (32.3%). The levels of inflammation markers (i.e.,
C-reactive protein and PAI-1) were significantly higher among patients with metabolic syndrome.
Conclusions: Patients with schizophrenia and recurrent depressive disorder demonstrate a high prevalence of metabolic
syndrome that is also related to inflammation processes. In the context of integrative medicine, clinicians and researchers should
consider psychiatric patients within a holistic approach.
Keywords
Hrčak ID:
162192
URI
Publication date:
18.9.2014.
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