Periodicum biologorum, Vol. 118 No. 2, 2016.
Short communication, Note
https://doi.org/10.18054/pb.2016.118.2.3655
Evaluating unspecific oxidative stress parameters in the sera of patients with irritable bowel syndrome
Emel Yigit Karakas
; Harran University, Faculty of Medicine Department of Internal Medicine, Sanliurfa/Turkey
Timucin Aydogan
; Harran University School of Medicine Department of Gastroenterology, Sanliurfa/Turkey
Hatice Sezen
; Harran University School of Medicine Department of Biochemistry, Sanliurfa/Turkey
Turgay Ulas
; Harran University, Faculty of Medicine Department of Internal Medicine, Sanliurfa/Turkey
Abstract
Objective: Irritable bowel syndrome (IBS) is a common global condition characterized by abdominal pain and alterations in bowel habits not caused by other organic diseases and its etiopathogenesis has not been elucidated. In this study, we aimed to evaluate the oxidative stress parameters in patients with IBS.
Materials and methods: Fifty patients diagnosed with IBS using the Rome III criteria and a control group of 50 healthy subjects were included in the study. Oxidative stress parameters including total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) values were analyzed from all study subjects.
Results: Compared to the controls; the TOS and OSI values were significantly higher, and the TAS value was significantly lower in IBS patients (p < 0.001 for all).
Conclusions: In present study we demonstrated that oxidative stress increased and antioxidant capacity decreased in IBS, and antioxidants might be beneficial in the supportive treatment for IBS.
Keywords
Irritable bowel syndrome; total oxidant status; total antioxidant status; oxidative stress index
Hrčak ID:
162223
URI
Publication date:
30.6.2016.
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