Psychiatria Danubina, Vol. 27 No. 3, 2015.
Conference paper
PERSONALIZED TREATMENT OF SCHIZOPHRENIA IN EVERYDAY CLINICAL PRACTICE: REALITY OR FICTION?
Blanka Kores Plesničar
; University Psychiatric Hospital Ljubljana, Ljubljana, Slovenia
Abstract
Each day clinical practice tries to follow the idea and principles of personalized medicine. Besides predicting an individual’s
sensibility or predisposition for developing schizophrenia, pharmacogenetic and pharmacogenomic approaches attempt to define
and acknowledge important indicators of clinical response to antipsychotics namely their efficacy and adverse effects. The main
focus of our article were not facts regarding the role CYP450 liver enzymes have in this; our purpose is introducing other, new
genetic and epigenetic factors which could introduce important biomarkers in diagnostics of the disease itself, the efficacy and
tolerance for antipsychotics. There is still a huge gap between gathering and collecting information and using them for the
personalized treatment of schizophrenia. From the genetic point of view personalized treatment of schizophrenia is the field we need
to focus on and successfully incorporate it our everyday clinical practice in the future.
Keywords
schizophrenia - personalized medicine – pharmacogenetics – pharmacogenomics - antipsychotics
Hrčak ID:
162491
URI
Publication date:
23.9.2015.
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