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https://doi.org/10.21860/52;3_421
Case report of the secondary breast angiosarcoma
Elvira Mustać
; Zavod za patologiju i patološku anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Franjo Carović
; Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Josip Aničić
; Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Matea Tomasić
; Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Lucija Beram
; Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Abstract
Aim: Secondary angiosarcoma of the breast is a rare but severe long-term complication of breast carcinoma treated with breast-conserving surgery and radiotherapy. We report here a case which occurred seven years after radiotherapy to highlight the awareness of the disease and the role of careful histological evaluation of these tumours. Case report: The 66-year-old patient with right breast infiltrating ductal carcinoma in December 2006. She underwent conservative breast surgery and sentinel lymph node dissection (pT1c, pN0). Her postoperative treatment included radiotherapy and endocrine therapy. Seven years after the radiotherapy (2013), the patient noticed a purplish spot in the skin of the previously irradiated field of the right breast. The histopathology reviewed a diagnosis of angiosarcoma. Conclusion: The development of secondary angiosarcoma has been linked to radiotherapy (RIA) and chronic lymphedema (Stewart–Treves syndrome) after median latency period of 4–8 years. Because of their rarity and seemingly harmless presentation, frequently comprising painless and bruise like skin lesions, both patients and doctors often neglect the initial symptoms and diagnosis is delayed.
Keywords
angiosarcoma; breast carcinoma; radiation therapy
Hrčak ID:
163938
URI
Publication date:
1.9.2016.
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