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Acta medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske, Vol. 70 No. 2, 2016.

Review article

FILLAGRIN – MULTIFUNCTIONAL PROTEIN

IVANA ČEPELAK ; University of Zagreb, Faculty of Pharmaceutics and Biochemistry, Zagreb, Croatia
SLAVICA DODIG ; University of Zagreb, Faculty of Pharmaceutics and Biochemistry, Zagreb, Croatia
JELENA FILIPOVIĆ GRČIĆ ; University of Zagreb, Faculty of Pharmaceutics and Biochemistry, Zagreb, Croatia

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Abstract

Effective physical, chemical, biochemical and immune function of the skin requires a corresponding structure of the epidermis. Filaggrin, one of epidermal proteins, is essential for the formation of corneocytes and intracellular metabolites, which in turn contribute to maintaining the stratum corneum humidity and acidic pH of the skin surface. However, a number of profi laggrin gene mutations have been described, as well as different infl ammatory conditions and different external factors that all resulted in fi laggrin defi ciency. Filaggrin defi ciency is recorded in different skin diseases and discoveries related to metabolic processing of fi laggrin point to new goals in therapeutic strategies. In this preview, the main properties
of the formation and metabolism of fi laggrin are described, as well as clinical implications of fi laggrin defi ciency in the etiopathogenesis of some skin diseases.

Keywords

stratum corneum; fillaggrin, profillaggrin; natural moisturizing factor; atopic dermatitis

Hrčak ID:

165171

URI

https://hrcak.srce.hr/165171

Publication date:

7.9.2016.

Article data in other languages: croatian

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