Original scientific paper
The activity of adenosinetriphosphase, 5-nucleotydase and alkaline phosphatase in blood and tissues in guinea pigs exposed to nitrogen oxides
S. Košmider
; II Clinic of Internal Diseases, Institute of Internal Diseases, Silesian School of Medicine, Katowice, Poland
Abstract
The effect of long-term exposure of animals to nitrogen oxides at a concentration of 1 mg/m3 on the activity of ATP-ase, 5-nucleotydase and alkaline phosphatase in the blood, brain and liver was investigated. It was shown that a decrease in the activity of enzymes localized in cell membranes and involved in active transport was brought about by the toxic effect of nitrogen oxides. The elimination of magnesium, an activator of several membrane enzymes occurred as a consequence of the impairment of membranes which results from peroxidation of lipids of cell membranes. This phenomenon intensifies secondary disturbances in the activity of the studied enzymes. The binding of nitrogen oxides to gaseous ammonia leads to the formation of products which do not cause changes induced by nitrogen oxides only.
Keywords
Hrčak ID:
165207
URI
Publication date:
29.6.1977.
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