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PUVA-induced Bullous Pemphigoid in Psoriasis

Nina Caca Biljanovska ; University of Ss. Cyril and Methodius, Department of Dermatology, Skopje, Macedonia
Irina Arsovska Bezhoska ; University of Ss. Cyril and Methodius, Department of Dermatology, Skopje, Macedonia
Marija V'lckova Laskoska ; University of Ss. Cyril and Methodius, Department of Dermatology, Skopje, Macedonia

Abstract

The association between psoriasis vulgaris and bullous pemphigoid is due to the still unclear autoimmune process. The common place of action is dermo-epidermal junction or basal membrane zone (BMZ) with specific alterations for both diseases. Photochemotherapy (PUVA) as one of the therapeutic modality for psoriasis can trigger production of autoantibodies against antigens in BMZ in patients with subclinical bullous pemphigoid. Furthermore, PUVA therapy can alter immunological milieu and hence can contribute to the expression of bullous pemphigoid in patients with psoriasis. Cumulative dose of PUVA, sufficient for triggering blister formation is individually determined. We observed a bullous eruption compatible with bullous pemphigoid in a psoriatic patient treated with PUVA. We proposed the implementation of the term - psoriasis pemphigoidesfor this atypical, compound form of psoriasis, when typical bullous pemphigoid lesions develop in typical psoriasis.

Keywords

Hrčak ID:

165618

URI

https://hrcak.srce.hr/165618

Publication date:

13.9.2016.

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