Original scientific paper
Effect of mono- and bis - quaternary pyridinium oximes on the acute toxicity and on the serumcholinesterase inhibitory activity of Dioxacarb Carbaryl and Carbofuran
B. Bošković
; Army Technical Institute, Beograd and »Bosnalijek«, Sarajevo, Yugoslavia
V. Vojvodić
; Army Technical Institute, Beograd and »Bosnalijek«, Sarajevo, Yugoslavia
M. Maksimović
; Army Technical Institute, Beograd and »Bosnalijek«, Sarajevo, Yugoslavia
Azra Granov
; Army Technical Institute, Beograd and »Bosnalijek«, Sarajevo, Yugoslavia
Svetlana Besarović-Lazarev
; Army Technical Institute, Beograd and »Bosnalijek«, Sarajevo, Yugoslavia
Z. Binenfeld
; Army Technical Institute, Beograd and »Bosnalijek«, Sarajevo, Yugoslavia
Abstract
The acute toxicities of insecticidal carbamates (Dioxacarb, Carbaryl and Carbofuran) were determined in mice by s. c. or i. p. injection, both in the absence and in the presence of atropine and several pyridinium oximes. Atropine had a beneficial effect on the toxicity of all the three carbamates, while the oximes varied in their effects. In the case of Carbaryl all oximes used increased its toxicity, while in Dioxacarb and Carbofuran poisoning some of them were effective. It was found that the oximes do not influence the action of carbamates on the activity of serum cholinesterase in vitro, in a way which could explain their effect on the toxicity of these compounds. It is concluded, that the use of oximes is contraindicated in cases of intoxication with Carbaryl, Dioxacarb and Carbofuran.
Keywords
Hrčak ID:
165718
URI
Publication date:
15.3.1977.
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