Original scientific paper

Acute toxicity and cholinesterase inhibition in vivo of chlorthiophos

G. Muačević ; C. H. Boehringer Sohn, Abt. Pharmakologie, Ingelheim am Rhein, F. R. Germany

Abstract

The acute toxicity of chlorthiophos with a chief component 0,0-diethyl-0-[2,5-dichloro.4-(methylthio) phenyl] thionophosphate, combined with 0,0-diethyl-0-[ 4,5-dichloro-2-(methylthio) phenyl] thionophosphate and 0,0-diethyl-0-[2,4-dichloro-5-(methylthio) phenyl] thionophosphate is described. The oral LD50 values obtained are: rat, 13 mg/kg; mouse, 141 mg/kg; guinea-pig, 511 mg/kg; rabbit, 20 mg/kg; quaal, 45 mg/kg; hen, 45 mg/kg, and dermal LD50 for: rat, 58 mg/kg and for rabbit, 48 mg/kg. No signs of neurotoxicity in hens were observed. In rats, a maximal inhibition of erythrocyte cholinesterase was found after two hours, of plasma cholinesterase after four and of brain cholinesterase after six hours, with a reversal to normal in the blood observed after four days and in brain after eight days. Lindane and phenobarbital pretreatment reduced the acute toxicity of chlorthiophos. Atropine and some oximes (obidoximechloride and trimedoximebromide) antagonized the toxic effects of chlorthiophos.

Keywords

Hrčak ID:

166181

URI

https://hrcak.srce.hr/166181

Publication date:

21.6.1976.

Article data in other languages: croatian

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