Original scientific paper
Brain cholinesterase activity changes in mice treated with o-ethyl-s-(2-diisopropyl-aminoethyl) methyl thiophosphonate (VX) and exposed to high oxygen concentrations in the air
R.C. Jović
; Neuropsihijatriiska bolnica, Kovin
Abstract
The effect of the length of exposure to high oxygen concentrations on acethylcholinesterase activity has been studied in the cortical slices of normal and VX poisoned mice. An 8-hour exposure had no effect on enzyme activity in either group of mice, regardless of whether they were protected with oximes or not. However, the mice exposed to high oxygen concentrations for 15 to 30 days showed a considerably higher AChE activity as compared with controls. This was clearly shown even in intact mice whose brain cholinesterase activity was 10 to 40 percent higher than in intact mice kept in the normal atmosphere. In the mice protected with oximes enzyme·reactivation was somewhat faster than in controls. It is concluded that a high oxygen concentration in the breathing air may cause an Increase an AChE actlvity in intact animals end stimulate boot the spontaneous and oxime induced enzyme reactivation in VX poisoned mice.
Keywords
Hrčak ID:
166190
URI
Publication date:
21.6.1976.
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