Original scientific paper
Validation of Epstein Biopsy Criteria for Insignificant Prostate Cancer in Contemporary Cohort of Croatian Patients
Igor Tomašković
orcid.org/0000-0003-4182-9707
; University Department of Urology , « Sestre milosrdnice» University hospital, Zagreb, Croatia
Monika Ulamec
; Department of Pathology University Hospital
Miroslav Tomić
; Department of Urology University Hospital
Ivan Pezelj
; University Department of Urology , « Sestre milosrdnice» University hospital, Zagreb, Croatia
Igor Grubišić
; University Department of Urology , « Sestre milosrdnice» University hospital, Zagreb, Croatia
Božo Krušlin
; University Department of Pathology «Ljudevit Jurak « , « Sestre milosrdnice « University hospital , Zagreb, Croatia
Abstract
Only few reports validated contemporary Epstein criteria for insignificant prostate cancer, and only one being from Europe. Patients with insignificant prostate cancer should be offered active surveillance and spared radical treatment. In our study we tested Epstein biopsy criteria for predicting unfavorable final pathology and biochemical relapse in low risk prostate cancer patients, who were eligible for active surveillance but where treated with radical prostatectomy. Between January 2003 and January 2008, 586 patients were subjected to radical prostatectomy in our institution. Among them, 106 where eligible for active surveillance according to Epstein biopsy criteria for insignificant prostate cancer. We analyzed the presence of adverse pathological findings in the final pathohistological specimen after radical prostatectomy which excludes low risk disease. Adverse pathohistological findings were noted in 41 (38.6 %) patients, who could have been offered active surveillance. During the follow up of 48 (12 – 72) months, biochemical relapse was noted in 6 (5.6%) patients. Although active surveillance is becoming more popular because of the long natural course of prostate cancer and fear of overtreatment of patients with indolent course of disease, both doctors and patients must be aware of potentially significant disease in this group and limitations of current preoperative criteria defining low risk patients.
Keywords
active surveillance; prostate cancer; low – risk prostate cancer; radical prostatectomy
Hrčak ID:
166284
URI
Publication date:
20.11.2015.
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