Review article
Welcome to the emerging third era of antimicrobial therapy
Ivan Kosalec
; Farmaceutsko-biokemijski fakultet u Zagrebu, Zavod za mikrobiologiju, Zagreb, Hrvatska
Abstract
The problem of antimicrobial resistance (AMR) could be seen as a global, complex and systemic problem with social, cultural and political consequences. There are several strategies how to overcome AMR, but today we need a unique global and solidary strategy to combat this slowly emerging and progressive disaster. Because all stakeholders in this dynamic challenging process are involved, scientists are also under public pressure to resolve this problem. Nowadays, scientific approach to combat AMR is focused on the need for a specific therapy. This approach includes the use of therapeutic monoclonal antibodies, microbial virulence inhibitors, bacteriophage lysins, antimicrobial proteins, potentiators of current antibiotics, immunomodulators, etc. These approaches, most of which are microbe-specific oriented, introduce us to the third era of antimicrobial therapy, which slowly arises from the domination of molecular paradigmatic era of antibiotics.
Keywords
Antimicrobial therapy; alternative approach; microbial resistance to antibiotics; resistance
Hrčak ID:
166691
URI
Publication date:
31.12.2015.
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