Original scientific paper

https://doi.org/10.2478/v10007-007-0032-6

Synthesis and biological evaluation of thieno[2,3-d]pyrimidines derivatives as anti-inflammatory, analgesic and ulcerogenic activity

ABDEL-RAHMAN. B. A. EL-GAZZAR
HODA A. R. HUSSEIN
HEND N. HAFEZ

Abstract

5-Methyl-6-phenyl-2-thioxothieno[2,3-d]pyrimidone derivative (2) reacted with hydrazonoyl chloride derivatives to afford triazolothienopyrimidones 4a-f. Also, acetone-1-(2-amino-5-isopropyl-thiophene-3-carbonitrile) (3) reacted with functional and bifunctional groups to yield the corresponding compounds 5-11. The new products showed anti-inflammatory, analgesic, and ulcerogenic activities comparable to that of indomethacin and acetylsalicylic acid, respectively.

Keywords

triazolothienopyrimidine; thienopyrimidines; thieno[2,3-d][1,3]thiazine; thieno-pyridines; analgesic; anti-inflammatory; ulcerogenic activity

Hrčak ID:

16244

URI

https://hrcak.srce.hr/16244

Publication date:

1.12.2007.

Article data in other languages: croatian

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