Professional paper

Implementation mechanisms of psychosomatic disorders in gastroesophageal reflux disease with concomitant chronic obstructive pulmonary disease

Aleksey Oparin Anatoliyovych ; Kharkiv Medical Academy of post-graduate education, Department of therapy, rheumatology and clinical pharmacology
Nataliia Beziazychna Vasylivna orcid.org/0000-0003-1493-9353 ; Kharkiv Medical Academy of post-graduate education, Department of therapy, rheumatology and clinical pharmacology

Abstract

Nowadays, gastroesophageal reflux diseases and chronic obstructive pulmonary diseases are among the most commonly occurring diseases. In most cases these diseases occur combined. Considering the fact that psychosomatic disorders play a major role in the formation of gastroesophageal reflux diseases and chronic obstructive pulmonary diseases, researching their implementation with the combined course of these diseases represents scientific and practical interest. Therefore, the aim of our research was to investigate the mechanisms of implementation of psychosomatic disorders in this comorbidity. During our research, we took two groups of patients. The first group consisted of patients with gastroesophageal reflux disease combined with chronic obstructive pulmonary disease. The second group consisted of patients with isolated gastroesophageal reflux disease. In addition to the standard methods of research, gastroesophageal reflux disease and chronic obstructive pulmonary disease, the level of melatonin, norepinephrine, and psychosomatic status indicators were also researched. As a result, it was found that patients with comorbid pathology had significantly higher indicators of depression, but indicators of melatonin and respiratory function significantly lower not only with persons in the control group, but also in patients with isolated gastroesophageal reflux disease. At the same time, patients with gastroesophageal reflux disease without comorbidity pathology had significantly higher indicators of reactive and personal anxiety, norepinephrine, and pH meters not only in the control group, but also in comparison with gastroesophageal reflux disease patients with concomitant chronic obstructive pulmonary disease. Thus, the obtained results indicate that patients with gastroesophageal reflux disease combined with concomitant chronic obstructive pulmonary disease have psychosomatic disorders, primarily due to depressions, that lead to the decreasing of melatonin levels and external respiration parameters which leads to the reduction of protective properties of the esophagogastric junction. Psychosomatic disorders of patients with isolated gastroesophageal reflux disease lead to increased production of norepinephrine and hydrochloric acid, first of all, due to increasing reactive and personal anxiety level, and thereby contribute to the increase in aggression factor level. The acquired data testify the role of psychosomatic disorders in creating the basic and accompanying pathology which requires differentiated treatment, aimed at increasing of protective properties of the first group of patients, and reducing aggression factors of the second group of patients.

Keywords

Gastroesophageal reflux disease; chronic obstructive pulmonary disease; psychosomatic disorders; melatonin; norepinephrine

Hrčak ID:

167277

URI

https://hrcak.srce.hr/167277

Publication date:

30.9.2016.

Article data in other languages: croatian

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