Review article

https://doi.org/10.11613/BM.2016.048

Unusual pattern in haemoglobin electrophoresis in Croatian population: a case report

Dragana Šegulja ; University Hospital Centre Zagreb, Department of Laboratory Diagnostics, Zagreb, Croatia
Danica Matišić ; University Hospital Centre Zagreb, Department of Laboratory Diagnostics, Zagreb, Croatia
Lorena Honović ; General Hospital Pula, Laboratory of Clinical Chemistry, Pula, Croatia
Josip Batinić ; University Hospital Centre Zagreb, Department of Internal Medicine, Zagreb, Croatia
Dunja Rogić ; University Hospital Centre Zagreb, Department of Laboratory Diagnostics, Zagreb, Croatia

Abstract

Haemoglobinopathies are hereditary disorders of globin chain synthesis and are the most common inherited diseases worldwide. Haemoglobin E is a structural haemoglobin variant characteristic for South East Asian population. We present a rare and unusual finding of haemoglobin E detected in University Hospital Centre Zagreb by capillary zone electrophoresis. Detection of haemoglobin structural variant helped to avoid misdiagnosis of sideropenic anemia and thus potentially harmful therapeutic intervention. In today’s European multiethnic population haemoglobinopathies are a public health issue and Croatian laboratory professionals should be aware of a possibility of finding an unusual haemoglobin pattern.

Keywords

HbE; haemoglobinopathies; capillary zone electrophoresis

Hrčak ID:

167753

URI

https://hrcak.srce.hr/167753

Publication date:

15.10.2016.

Visits: 1.094 *