Original scientific paper
Comparative metabolism of high lead dose levels in suckling and adult rats
B. Momčilović
; Institute for Medical Research and Occupational Health, Yugoslav Academy of Sciences and Arts, Zagreb
Abstract
The kinetics of lead distribution and retention was studied in 15 and 120 day-old rats after a single intraperitoneal application of 500 µg Pb/kg body weight labelled with tracer amount of 203Pb. After eight days the percentage 208Pb retention was about eight times higher in the brain, twice higher in the femur and liver and half as high as in the whole blood and teeth, but two times lower in the kidneys in sucklings as compared to adults. These differences are in agreement with our previous studies on the kinetics of tracer doses of lead in young and adult rats. The higher lead dose level used in this experiment caused a higher percentage of lead retention and a slower lead elimination in tissues of both suckling and adult rats.
Keywords
Hrčak ID:
167762
URI
Publication date:
17.12.1974.
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