Original scientific paper
Results of the Determination of Serum Markers in Patients with Malignant Melanoma
Liborija Lugović
Mirna Šitum
Marija Buljan
Sanja Poduje
Klaudija Šebetić
Abstract
Although there is no routine procedure for determination of serum markers in patients with malignant melanoma
(MM), some markers are being studied as potentially useful prognostic tools. Serum lactate dehydrogenase (LDH), protein
S-100B, melanoma-inhibiting activity (MIA) and tyrosinase may correlate with melanoma progression. In this
study, the results of determination of S100 protein, LDH, MIA and tyrosinase in the serum of 50 patients with MM
(stages I-IV) were determined. The increased values of MIA were found in 26% patients in stage I, while in 50% patients
in stage IV. Increased S-100 protein was found in 13% patients in stage I while in 50% patients in stage IV. The increased
values of LDH were found in 26% patients in stage I, while in 25% patients in stage IV. The positive serum tyrosinase was
noticed in 17.3% patients in stage II, while in 25% patients in stage IV. The obtained results have revealed no significant
differences between the groups in higher and lower stages of the disease, indicating that blood markers are not reliable
prognostic factors for MM progression.
Keywords
malignant melanoma; markers; lactate dehydrogenase (LDH); protein S-100; melanoma-inhibiting activity (MIA); tyrosinase
Hrčak ID:
16382
URI
Publication date:
16.1.2007.
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