Original scientific paper
Aromatic phosphoryl thiocholines. III. The kinetics of inhibition of purified horse serum cholinesterase
M. Maksimović
; Institute of Technical and Medical Protection, Beograd
M. Ćosić
; Institute of Technical and Medical Protection, Beograd
Z. Binenfeld
; Chemical Plant Chromos-Katran-Kutrilin, Zagreb
Abstract
Kinetics and thermodynamics of inhibition of purified horse serum cholinesterase by seven 0-ethyl-S-[(2-N-methyl-N-arylamino) ethyl]methyltiophosphonates and seven O-ethyl-S[(2-N-methyl-N-arylammonium)ethyllmethylthiophosphonate methosutphates of the general formula where R = H, -CH3, -OCH3 and -Cl, in m and p positions. For compounds A the k, varied from (0,056-0,284) · 105 M-1 min-1, and for compounds B from (1,95 - 29,4) · 105 (M-1 · min-1). Activation energy (E) for the former class varied from 4,2 to 14,38 kcal/mol, and for the latter from 6,87 to 10,06 kcal/mol. The preexponential factor for the two classes (log A) varied from 7,53 to 14,22 and from 11,16 to 13,7 respectively.
Keywords
Hrčak ID:
168280
URI
Publication date:
11.9.1973.
Visits: 676 *