Original scientific paper
Comparison between inhibition of acetylcholinesterase and cholinesterase by some n-methyl - and NN-dimethyl-carbamates
Vera Simeon
; Institute for Medical Research, Yugoslav Academy of Sciences and Arts, Zagreb
Elsa Reiner
; Institute for Medical Research, Yugoslav Academy of Sciences and Arts, Zagreb
Abstract
Second order rate constants for inhibition (ka) of various sources of acetylcholinesterase (EC 3.1.1.7) and cholinesterase (EC 3.1.1.8) with seven N-methyl- and two NN-dimethylcarbamates are given in tabular form. A comparison between acetylcholinesterase and cholinesterase is presented for different stages of the time course of the reaction: at pre-steady state the comparison is based on ka values, and at steady state on the K values (apparent equilibrium constants for enzyme and inhibitor). When two enzymes are inhibited by the same compound, the difference in the degree of inhibition at steady state and pre-steady state will be greater the greater the difference in the stability of the carbamylated enzymes
Keywords
Hrčak ID:
168383
URI
Publication date:
13.12.1973.
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