Medicina Fluminensis, Vol. 52. No. 4., 2016.
Original scientific paper
https://doi.org/10.21860/medflum2016_4poa
Long-term outcome in children with prenatally diagnosed central nervous system congenital malformations
Igor Prpić
; Klinika za pedijatriju, KBC Rijeka, Rijeka
Vesna Mahulja Stamenković
; Klinika za ginekologiju i porodništvo, KBC Rijeka, Rijeka
Oleg Petrović
; Klinika za ginekologiju i porodništvo, KBC Rijeka, Rijeka
Ivana Kolić
orcid.org/0000-0002-5337-4968
; Klinika za pedijatriju, KBC Rijeka, Rijeka
Abstract
AIM: Aim of this study was to show epidemiologic data and long-term outcome of prenatally detected central nervous system congenital malformations (CNS-CM) in Clinical Hospital Center Rijeka.
METHODS: The data were collected retrospectively and partially prospectively in the last decade (2006-2015) by European registry for monitoring congenital anomalies protocol. During study period there were 30 131 births with total of 53 fetuses with isolated or multiple CNS-CM, which makes a total of 0.17% of births. There were 57 malformations.
RESULTS: The most common malformations where defects of the neural tube 26/57 (46%), hydrocephalus 10/57 (17.5%), agenesis of corpus callosum 6/57 (10.5%), holoprosencephaly 4/57 (7%), Dandy-Walker malformation 4/57 (7%) and other malformations 8/57 (14%), what was statistically significant (P=0.024). There where 18 livebirths and 4 stillbirths. Statistically significant was prenatal detection of malformation (P=0.025) in 49/57 (92.4%), and in 35/57 before 22nd week of gestation. Long-term outcome was evaluated in 16 of 18 livebirths, while data for two children was unknown. The average length of the follow-up was 5,3 years (Range:1-9 years). Two infants died within a period of three months, and one child died at age of 7 years and 9 months. The favourable outcome have 7/16 (44%) and the adverse long-term outcome have 9/16 (65%) children.
CONCLUSION: Our results show similar results of those in available literature, good prenatal screening in detecting CNS-CM, but the long-term outcome was not favourable in the majority of cases.
Keywords
central nervous system malformations; long-term outcome; prevalence
Hrčak ID:
168446
URI
Publication date:
1.12.2016.
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