Professional paper
The influence of lead and alcohol on urinary excretion of coproporphyrin, uroporphyrin and porphobilinogen
B. Radojičić
; Institut za medicinu rada Medicinskog fakulteta, Niš
Abstract
The concentrations of coproporphyrins, uroporphyrins and porphobilinogen were determined in 300 workers occupationally exposed to lead. The same analyses were done in 100 workers who were chronic alcoholics. The results were compared with those obtained in a control group which consisted of 50 nonexposed and 50 nondrinking workers. In lead exposed workers the excretion of coproporphyrins and uroporphyrins was increased. The increased excretion of porphobilinogen was found only in a few subjects. As a rule, uroporphyrins were elevated in cases of higher lead exposure, when urinary excretion of lead was also significantly increased. These data confirm that the determination of coproporphyrins in the urine is a significant labo-ratory test for the evaluation of lead exposure. In chronic alcoholics beside the increased excretion of uroporphyrins and coproporphyrins the elevated excretion of porphobilinogen is also important.
Keywords
Hrčak ID:
168620
URI
Publication date:
22.3.1973.
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