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Croatian Medical Journal, Vol. 57 No. 4, 2016.

Original scientific paper

https://doi.org/10.3325/cmj.2016.57.351

Angiotensinogen-M235T as a risk factor for myocardial infarction in Asian populations: a genetic association study and a bioinformatics approach

Fariba Raygan ; Department of Cardiology, School of Medicine, Kashan University ofMedical Sciences, Kashan, Iran
Mohammad Karimian ; Gametogenesis Research Center, Kashan University of MedicalSciences, Kashan, Iran
Atefeh Rezaeian ; Department of Molecular and Cell Biology, Faculty of Basic Sciences,University of Mazandaran, Babolsar,Iran
Bahareh Bahmani ; Anatomical Sciences Research Center, Kashan University ofMedical Sciences, Kashan, Iran
Mohaddeseh Behjati ; Cardiovascular research center, Cardiovascular Research Institute,Isfahan University of MedicalSciences, Isfahan, Iran

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Abstract

Aim To investigate if there is an association between
M235T polymorphism of angiotensinogen gene and myocardial
infarction (MI) risk and perform a meta-analysis and
an in silico approach.
Methods This case-control study included 340 participants
(155 MI patients and 185 controls) examined at
Kashan University of Medical Sciences (Kashan, Iran) between
2013 and 2015. Meta-analysis included 25 studies
with 6334 MI patients and 6711 controls. Bioinformatics
tools were applied to evaluate the impact of M235T polymorphism
on angiotensinogen function and structure.
Results Genetic association study revealed a significant association
between TT genotype (odds ratio [OR] 2.08, 95%
confidence interval [CI] 1.08-4.00, P = 0.029) and T allele (OR
1.45, 95% CI 1.06-1.99, P = 0.021) and MI risk. Meta-analysis
also revealed a significant association between M235T
polymorphism and MI risk in allelic (OR 1.55, 95% CI 1.10-
2.18, P = 0.012) and recessive (OR 1.69, 95% CI 1.13-2.53,
P = 0.010) models within Asian population. In silico-analysis
revealed that M235T fundamentally changed the function
of angiotensinogen (score 32; expected accuracy 66%).
Conclusions Our study suggests that M235T polymorphism
might be a helpful biomarker for screening of susceptible
individuals for MI in Asian population.

Keywords

Hrčak ID:

170337

URI

https://hrcak.srce.hr/170337

Publication date:

15.8.2016.

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