Liječnički vjesnik, Vol. 133 No. 1-2, 2011.
Review article
CLINICAL AND ETIOPATHOGENETIC ROLE OF PLASMINOGEN AND METOPROTEINASE SYSTEMS IN THE TUMOR GROWTH Pericellular proteolysis of extracellular matrix and tumor growth
Sanda Jelisavac Ćosić
Zdenko Kovač
Abstract
Pericellular proteolysis is a cascade process involved in degradation of extracellular matrix. This process is included in various physiological and pathological processes. Pericellullar proteolysis has major functions like degradation of tissue stroma and weakening of intercellular connections but it also has a function in the synthesis of bioactive molecules (cytokines, growth factors and inhibitory factors). Plasminogen system is involved in fibrinolysis and starts metalloproteinase activation. Activity of proteolytic molecules is controlled by the rate of zymogenic activation, half-life of molecules, and action of inhibitory molecules. Inhibition is achieved through direct binding of inhibitor and enzyme and takes a few steps. Pericellular proteolysis is involved in tumor invasion and metastasis, inflammatory reaction, degenerative diseases and other diseases. Pathophysiological regulation of pericellular proteolysis in mentioned diseases contributes to clinical properties of diseases and has diagnostic and therapeutic importance.
Keywords
Neoplasms – metabolism, pathology; Neoplasm metastasis – physiopathology; Extracellular matrix – meta bolism; Matrix metalloproteinases – metabolism; Tissue plasminogen activator – metabolism; Urokinase-type plasminogen activator – metabolism, analysis; Plasminogen activator inhibitor 1 – metabolism, analysis; Tumor markers, biological – analysis; Breast neoplasms – diagnosis, pathology
Hrčak ID:
171655
URI
Publication date:
28.2.2011.
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