Liječnički vjesnik, Vol. 133 No. 3-4, 2011.
Professional paper
SUGAMMADEX, A NEW DRUG FOR REVERSION OF MUSCLE RELAXANTS
Slavica Kvolik
Višnja Ikić
Marko Jukić
Abstract
Sugammadex is a new pharmacological agent for neuromuscular block reversion. It is a cyclic oligosaccharide, a gamma cyclodextrin with lipophylic inner coat that enables forming of stable complexes with steroidal neuromuscular blocking drugs, especially with rocuronium. A physical encapsulation of the relaxants is a novel elimination pathway and it produces fast and complete reversion of both deep and shallow neuromuscular block. Consequently, sugammadex has no unwanted cholinergic muscarinic effects observed with cholinesterase inhibitors such as bradycardia, hypersalivation, and increased gastrointestinal motility. Since the effects of sugammadex are dose dependent it can very rapidly reverse the effects of rocuronium. After the adjusted dose of sugammadex was given, the duration of action of rocuronium can be made as short as that of succinylcholine. This characteristic is especially important in the ’can’t intubate, can’t ventilate’ situation and after surgical procedure was unexpectedly finished. Clinical studies involving more patients are needed to show the real risk-benefit profile and safety in the special patients’ populations
Keywords
Gamma-cyclodextrins – pharmacology, administration and dosage, adverse effects; Neuromuscular nondepolarizing agents – administration and dosage, antagonists and inhibitors; Androstanols – administration and dosage, antagonists and inhibitors; Vecuronium bromide – administration and dosage, antagonists and inhibitors; Neuromuscular blockade – methods
Hrčak ID:
171665
URI
Publication date:
28.4.2011.
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