Original scientific paper

Anticonvulsant activity of Schiff bases of isatin derivatives

MANJUSHA VERMA
SURENDRA NATH PANDEYA
KRISHNA NAND SINGH
JAMES P. STABLES

Abstract

Schiff bases of N-methyl and N-acetyl isatin derivatives with different aryl amines have been synthesized and screened for anticonvulsant activities against maximal electroshock (MES) and subcutaneous metrazole (ScMet). N-methyl-5-bromo-3-(p-chlorophenylimino) isatin 2 exhibited anticonvulsant activity in MES and ScMet with LD50 > 600 mg kg-1, showing better activity than the standard drugs phenytoin, carbamazepine and valproic acid. Thus, compound 2 may be chosen as a prototype for development of new anticonvulsants.

Keywords

Schiff base; isatin; anticonvulsant

Hrčak ID:

16661

URI

https://hrcak.srce.hr/16661

Publication date:

1.3.2004.

Article data in other languages: croatian

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