Original scientific paper

https://doi.org/10.20471/acc.2016.55.03.10

Influence of fondaparinux versus nadroparin calcium thromboprophylaxis on clinical parameters following total knee arthroplasty

Zdravka Mihaljević ; Department of Orthopedic Surgery, Zagreb University Hospital Center, Zagreb, Croatia
Damjan Dimnjaković orcid.org/0000-0002-5726-4301 ; Department of Orthopedic Surgery, Zagreb University Hospital Center, Zagreb, Croatia
Branko Tripković ; Department of Orthopedic Surgery, Zagreb University Hospital Center, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia
Melita Buljan ; Department of Orthopedic Surgery, Zagreb University Hospital Center, Zagreb, Croatia
Ana Aljinović ; Department of Orthopedic Surgery, Zagreb University Hospital Center, Zagreb, Croatia
Domagoj Delimar ; Department of Orthopedic Surgery, Zagreb University Hospital Center, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia
Goran Bićanić ; Department of Orthopedic Surgery, Zagreb University Hospital Center, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia

Abstract

Fondaparinux has been shown to be as effective as low molecular weight heparin in orthopedic surgery, with no cases of heparin induced thrombocytopenia proven until today. The main goal of this prospective randomized controlled trial was to define whether thromboprophylaxis in patients with primary osteoarthritis of the knee undergoing total knee arthroplasty (TKA) influences clinical parameters in the same manner in patients receiving fondaparinux as in those receiving nadroparin during the first 7 postoperative days. Sixty patients with primary knee osteoarthritis underwent unilateral TKA performed by the same surgeon and were randomized into two groups of 30 patients receiving either fondaparinux or nadroparin thromboprophylaxis. Patients were compared according to the duration of operation, perioperative blood loss, laboratory results and clinical evaluation of the edema during the early postoperative period. No diff erences were found between the groups in the mean duration of surgery, perioperative blood loss, and most of laboratory results. The level of urea was significantly lower in the nadroparin group on the first and second postoperative day. No cases of heparin induced thrombocytopenia, deep vein thrombosis or pulmonary embolism were noted during the study. Study results showed both fondaparinux and nadroparin to have the same influence on clinical parameters during the first 7 postoperative days in patients undergoing TKA.

Keywords

Arthroplasty, replacement, knee; Anticoagulants; Fondaparinux; Nadroparin; Hemorrhage

Hrčak ID:

172581

URI

https://hrcak.srce.hr/172581

Publication date:

9.11.2016.

Article data in other languages: croatian

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