Review article

CORRELATION BETWEEN OBESITY AND PANCREATIC CANCER

Maja Pin
Davor Štimac

Abstract

Pancreatic cancer is an aggressive tumor with a very poor prognosis, lack of early diagnostic symptoms and highly resistant to therapy. Its incidence is approximately equal to the mortality rate. Even though in recent years progress has been made in defining the morphological and key genetic changes, it is still unclear which factors trigger its occurrence. Some risk factors are age, gender and race, genetic susceptibility, dietary factors, fever, chronic pancreatitis, diabetes and physical inactivity. Studies have shown that an increase in BMI consequently leads to an increased risk of malignancies, including pancreatic cancer. Research based on adipokines and their role in obesity and the occurrence of pancreatic cancer are the potential for a possible future therapeutic interventions.

Keywords

Pancreatic neoplasms – epidemiology, etiology; Obesity – epidemiology, physiopathology, prevention and control; Body mass index; Adipose tissue – metabolizam; Adiponectin – metabolism; Leptin – metabolism; Risk factors

Hrčak ID:

172714

URI

https://hrcak.srce.hr/172714

Publication date:

2.9.2015.

Article data in other languages: croatian

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