Review article

C1Q NEPHROPATHY: CASE REPORTS AND LITERATURE REVIEW

Krešimir Galešić
Ivica Horvatić
Danica Batinić
Dinko Milošević
Marijan Saraga
Merica Glavina Durdov
Danica Galešić Ljubanović

Abstract

C1q nephropathy is considered a form of glomerulonephritis, defined by histological findings of dominant C1q immune deposits in renal biopsy. It is a rare disease, most often manifested in children and young adults. The most common clinical manifestation of the disease is nephrotic syndrome, but other renal syndromes could also be found. The cause of the disease is not known, but the immune pathogenesis could be assumed. Often, resistance to glucocorticoid or other immunosuppressive therapy is present, potentially leading to chronic renal insufficiency. We present ten patients with renal biopsy and clinical findings of C1q nephropathy. None of the patients had clinical or serological manifestations of systemic lupus. All patients had normal findings of C3 and C4 components of complement, as well as normal ANF, anti-dsDNA and ANCA antibodies

Keywords

Glomerulonephritis – immunology, pathology, drug therapy; Complemet C1q – immunology; Glomerular mesangium – immunology, pathology; Kidney – immunology, pathology; Nephrotic syndrome – immunology, pathology, drug therapy; Immunosuppressive agents – therapeutic use; Glucocorticoids – therapeutic use

Hrčak ID:

172720

URI

https://hrcak.srce.hr/172720

Publication date:

29.10.2015.

Article data in other languages: croatian

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