Original scientific paper

Benzimidazolyl quinolinyl mercaptotriazoles as potential antimicrobial and antiviral agents

VINOD KUMAR PANDEY
MRIDULA UPADHYAY
MRINALINI UPADHYAY
VISHNU DEV GUPTA
MEENAL TANDON

Abstract

Condensation of ethylaceto acetate (EAA) with resorcinol in concentrated H2SO4 afforded 7-hydroxy-4-methyl coumarin (1) which on reaction with thiosemicarbazide in anhydrous pyridine yielded 7-hydroxy-4-methyl-quinolinyl [1,5-c]-mercaptotriazole (2). Reaction of 2 with formaldehyde solution and amino acid in ethanol yielded 7-hydroxy-4-methyl-8-(N-methyl-aminoacid)-quinolinyl [1,5-c]-2"-mercaptotriazole (3). Interaction of 3 with o-phenylenediamine in pyridine yielded 7-hydroxy-4-methyl-8-(aminobenzimidazolyl)-quinolinyl [1,5-c]-2"-mercaptotriazole derivatives (4a-e). The latter compounds were evaluated for their antiviral and antimicrobial activities.

Keywords

minimum inhibitory concentration; minimum essential medium; foetal bovine serum; cytotoxicity; mercaptotriazoles

Hrčak ID:

16744

URI

https://hrcak.srce.hr/16744

Publication date:

1.3.2005.

Article data in other languages: croatian

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