Original scientific paper

Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates

MARIJANA ZOVKO
MONIKA BARBARIC
BRANKA ZORC
ANITA HAFNER
JELENA FILIPOVIC-GRCIC

Abstract

Two types of polymer-drug conjugates were synthesized starting from styrene-maleic acid anhydride copolymer (SMA). Fenoprofen and gemfibrozil were chosen as model drugs because of their short plasma half lives. Both drugs were first converted to their 2-aminoethylamides, which possess free amino groups capable of reacting with SMA anhydride rings. By modifying the degree and type of substitution, lipophilic and hydrophilic conjugates were obtained. Drug loading in the conjugates was between 17 and 47%.

Keywords

fenoprofen; gemfibrozil; polymer-drug conjugate; macromolecular prodrug; styrene-maleic acid anhydride copolymer

Hrčak ID:

16754

URI

https://hrcak.srce.hr/16754

Publication date:

1.6.2005.

Article data in other languages: croatian

Visits: 3.005 *