Acta Pharmaceutica, Vol. 55 No. 3, 2005.
Original scientific paper
Synthesis of some oxazolinones and imidazolinones and their antimicrobial screening
BIPLAB DE
JAYANTA KUMAR GUPTA
VENKATAPURAM SAMPATH SARAVANAN
Abstract
A few imidazolinones [1-aminoethyl/phenyl-2-methyl/phenyl-4-acetylidene/benzylidene-imidazolin-5(4H)-ones] were newly synthesized from respetive acetylidene/benzylidene oxazolinones. Schiff's bases were synthesized by the reaction between imidazolinones and benzaldehyde. The antimicrobial screening of almost all compounds showed moderate to significant activities against B. subtilis ATCC 6633 and K. pneumoniae ATCC 25063. Compounds 10 [1-aminophenyl-2-phenyl-4-acetylidene-imidazolin-5(4H)-one] and 12 [1-aminophenyl-2-phenyl-4-benzylidene-imidazolin-5(4H)-one] showed even better activity than amphotericin B against C. albicans ATCC 29738.
Keywords
imidazolin-5(4H)-ones; oxazolinones; Schiff's bases; antimicrobial activity
Hrčak ID:
16765
URI
Publication date:
1.9.2005.
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