Original scientific paper

Preparation and evaluation of floating risedronate sodium Gelucire® 39/01 matrices

BHASKAR CHAUHAN
SHYAM SHIMPI
KAKASAHEB R. MAHADIK
ANANT PARADKAR

Abstract

Incorporation of bisphosphonates in the lipid reduces gastric irritation. Only gastric retention with sustained release allows the drug to reach the duodenum and jejunum and improves the availability of bisphosphonates. Risedronate sodium and Gelucire® 39/01 floating matrices were prepared using melt solidification. The sustained release floating matrices were evaluated for in vitro and in vivo floating ability and in vitro drug release. Ageing of the matrices was studied by differential scanning calorimetry, hot stage polarizing microscopy, scanning electron microscopy and in vitro drug release. Ageing causes changes in the crystal structure of the Gelucire®, which is responsible for increase in drug release.

Keywords

risedronate sodium; Gelucire® 39/01; hot stage polarizing microscopy; ageing, scanning electron microscopy

Hrčak ID:

16864

URI

https://hrcak.srce.hr/16864

Publication date:

1.9.2004.

Article data in other languages: croatian

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