Short communication, Note

Synthesis and potential antimycotic activity of 4-substituted-3-(thiophene-2-yl-methyl)- delta2-1,2,4-triazoline-5-thiones

MONIKA WUJEC
MONIKA PITUCHA
MARIA DOBOSZ
URSZULA KOSIKOWSKA
ANNA MALM

Abstract

In the reaction of hydrazide of thiophene-2-acetic acid (1) with isothiocyanates, the respective thiosemicarbazides 2a-g were obtained. Further cyclization with 2% NaOH led to formation of 4-substituted-3-(thiophene-2-yl-methyl)-delta2-1,2,4-triazoline-5-thiones (3a-g). These compounds showed promising antimycotic activity.

Keywords

4-substituted-3-(thiophene-2-yl-methyl)-delta2-1,2,4-triazoline-5-thiones; synthesis; spectral analysis; antimycotic activity

Hrčak ID:

16868

URI

https://hrcak.srce.hr/16868

Publication date:

1.9.2004.

Article data in other languages: croatian

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