Original scientific paper
The effect of phosphates on strontium and calcium metabolism in control, parathyroidectomized and parathormone-treated rats
Nevenka Gruden
; Institute for Medica! Research. Yugoslau Academy of Sciences and. Arts. Zagreb
L. Rabađija
; Institute for Medica! Research. Yugoslau Academy of Sciences and. Arts. Zagreb
Krista Kostial
; Institute for Medica! Research. Yugoslau Academy of Sciences and. Arts. Zagreb
Abstract
The influence of the phosphate content of the diet on strontium and calcium metabolism was studied in control, parathyroidectomized and parathormone treated rats after oral and intraperitoneal application of radioactive isotopes. It was shown that skeletal retention of radioactive calcium (45, 47Ca) and strontium (85Sr) and the 85Sr/45, 47Ca ratio depend upon the phosphate content in the diet as well as upon the route of radioactive isotope application. The effect of phosphates on calcium and strontium metabolism, however. does not depend upon the function of the parathyroid gland. In parathyroidectomized, parathormone-treated and control rats both the urinary elimination and gastrointestinal absorption of radiocalcium and radiostrontium are influenced by changes in dietary phosphates in the same way.
Keywords
Hrčak ID:
176849
URI
Publication date:
20.3.1968.
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