Acta Pharmaceutica, Vol. 54 No. 4, 2004.
Original scientific paper
Healing potential of Anogeissus latifolia for dermal wounds in rats
RAGHAVAN GOVINDARAJAN
MADHAVAN VIJAYAKUMAR
CHANDANA VENKATESHWARA RAO
ANNIE SHIRWAIKAR
SHANTA MEHROTRA
PALPU PUSHPANGADAN
Abstract
Wound healing potential of etnanolic extract of Anogeissus latifolia bark (ALE) for treatment of dermal wounds in rats was studied on excision and incision wound models. HPTLC of the total extract was recorded for the purpose of standardization. Various parameters of incision wound, viz. epithelization period, scar area, tensile strength and hydroxyproline measurements along with wound contraction, were used to evaluate the effect of A. latifolia on wound healing. The results obtained indicate that A. latifolia accelerates the wound healing process by decreasing the surface area of the wound and increasing the tensile strength. Nitrofurazone ointment was used as a positive control. Complete epithelization was observed within 15 days with ALE. Measurements of the healed area and the hydroxyproline level were in agreement. Antibacterial activity of ALE was studied against Gram-positive (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae) compared to erythromycin and tetracycline. Moderate activity was observed against all organisms. The present study provides a scientific rationale for the traditional use of Anogeissus latifolia in the management of skin diseases such as sores, boils and itching.
Keywords
Anogeissus latifolia (Combretaceae); wound healing; antibacterial activity; HPTLC
Hrčak ID:
16908
URI
Publication date:
1.12.2004.
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