Original scientific paper
Correlation between protein nm23 and cathepsin D with clinical and pathological features of oral squamous cell carcinoma
Čedna Tomasović Lončarić
; Clinical Hospital Dubrava, Zagreb, Croatia
Vanja Vučičević Boras
orcid.org/0000-0003-1651-8069
; Department of Oral Medicine, School of Dental Medicine, University of Zagreb; University Dental Clinic, University Hospital Center Zagreb, Zagreb, Croatia
Dragana Gabrić
; Department of Oral Surgery, School of Dental Medicine, University of Zagreb, Croatia; University Dental Clinic, University Hospital Center Zagreb, Zagreb, Croatia
Maša Filipović
; School of Dental Medicine and Clinical Hospital Center Zagreb, Zagreb, Croatia
Igor Blivajs
; Clinical Hospital Dubrava, Zagreb, Croatia
Matej Andabak
; Clinical Hospital Dubrava, Zagreb, Croatia
Larisa Musić
; Department of Periodonology, School of Dental Medicine Zagreb, Croatia
Abstract
The most important prognostic factor in oral squamous cell carcinoma (OSCC) is the presence of metastases in regional lymph nodes. Study group comprised of 107 patients with OSCC and control group comprised of 77 specimens of unchanged oral mucosa. The purpose of this study was to determine the immunohistochemical expression of cathepsin D and nm23 protein in OSCC and to compare it to the other clinical and histological features and to the occurrence of regional metastases, in order to assess their prognostic value. In contrast to normal epithelium a diff use expression of cathepsin D and nm23
protein in OSCC has been found. By comparing the expression of cathepsin D and nm23 protein in tumor cells and in tumor stroma and the type of reaction to the pT, the degree of diff erentiation, mode of invasion and tumor stroma the following has been found: a signifi cant connection between nm23 protein in tumor cells with the degree of diff erentiation, nm23 protein with the characteristics of the tumor stroma and mode of invasion and cathepsin D with the degree of tumor diff erentiation. The results of this research highlight the important role of tumor stroma in metastatic potential of OSCC.
Keywords
squamous cell carcinoma; nm23 protein; cathepsin D
Hrčak ID:
177103
URI
Publication date:
28.12.2016.
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