Original scientific paper

A Spectrophotometric and Polarographic Investigation of Some New Precursors of Potential Antineoplastic Compounds

Rajeev Jain ; School of Studies in Chemistry, Jiwaji University, Gwalior-474011 (India)
Anju Dixit ; School of Studies in Chemistry, Jiwaji University, Gwalior-474011 (India)

Abstract

The present paper summarises the electrochemical behaviour
of 2-benzothiazolylhydrazono-l-(N -phenylamino)-1,3-butane diones
with special reference to the effect of substituents, ionic- strength and solvent composition on their redox mechanism. The reduction of the hydrazones takes place in a single 4e wave at D.M.E. All the compounds gave a single, well defined, irreversible, diffusion controlled reduction wave whose Et!, is pH-dependent. A plausible mechanism is also suggested on the basis of the number of protons involved in the rate determining step and the number of electrons involved in the reduction. The effect of substituents is interpreted in the terms of the Hammett equation. The pK values were calculated by polarographic and spectrophotometric methods.

Keywords

Hrčak ID:

177378

URI

https://hrcak.srce.hr/177378

Publication date:

20.6.1986.

Visits: 628 *