Periodicum biologorum, Vol. 118 No. 4, 2016.
Review article
https://doi.org/10.18054/pb.v118i4.4576
Podocytes and the actin cytoskeleton as a feasible therapeutic target
Sanja Sever
; Harvard Medical School and Massachusetts General Hospital, Charlestown, MA
Changkyo Gu
; Harvard Medical School and Massachusetts General Hospital, Charlestown, MA
Abstract
Podocyte injury is a hallmark of the glomerular disease, which is a direct cause of chronic kidney diseases. Importantly, podocyte injury is a consequence of the dysregulation of the actin cytoskeleton. In diverse animal models of proteinuric glomerular disease, recovering the integrity of the actin structure in podocytes resulted in beneficial effects. In this review, we focus on the premise of targeting the actin cytoskeleton as a feasible therapeutics for treating chronic kidney diseases
Keywords
Hrčak ID:
177545
URI
Publication date:
17.3.2017.
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