Original scientific paper

Influence of some chelating agents on radiostrontium metabolism

Krista Kostial ; Institut za medicinska istraživanja i medicinu rada Jugoslavenske akademije znanosti i umjetnosti, Zagreb
S. Vojvodić ; Institut za medicinska istraživanja i medicinu rada Jugoslavenske akademije znanosti i umjetnosti, Zagreb
Tea Maljković ; Institut za medicinska istraživanja i medicinu rada Jugoslavenske akademije znanosti i umjetnosti, Zagreb

Abstract

The efficiency of newly synthesized chelating agents CPDTA (cyclopentanediamine tetraacetic acid), DIMEDTA (dimethylethylenediamine tetraacetic acid), and PDTA (propylenediamine tetraacetic acid) in influencing the skeletal retention of radiostrontium was tested on rats. The intraperitoneal injection of radioactive strontium was immediately followed by an intraperitoneal injection of the chelating agents applied as disodium salts of strontium chelates at a dose of 0.8 m mole/kg. The retention of strontium-85 in the skeleton was measured 72 hours after the injection. It was found out that only CPDT A with the higher stability constants for calcium and strontium and lowest ratio of constants caused a 20% reduction of radiostrontium retention. The effect was independent of the age and sex of animals and the way of parenteral application of radioactive strontium (subcutaneous or intraperitoneal injection). Rats treated with strontium chelates of CPDTA, EDTA (ethylenediamine tetraacetic acid), BADE (2:2 bis [di(carboxymethyl)amino]dietylether) immediately after an oral application of radioactive stroncium by stomach tube showed an increased skeletal radiostrontium retention of 25-50%. The authors consider this a new additional difficulty in applying the therapy with chelating agents in the case of radioactive strontium contamination.

Keywords

Hrčak ID:

177601

URI

https://hrcak.srce.hr/177601

Publication date:

28.6.1967.

Article data in other languages: croatian

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