Original scientific paper

1,3 - acetone bis (4 - hydroxyiminoformyl pyridinium) dibromide (MBM - 3): chemical properties, cholinesterase reactivation, protective action in experimental paraoxon poisoning

Z. Binenfeld ; Department of Pharmacology, Faculty of Medicine, Beograd, and High Military Technical School, Zagreb
D. Anđelković ; Department of Pharmacology, Faculty of Medicine, Beograd, and High Military Technical School, Zagreb
M. Milojević ; Department of Pharmacology, Faculty of Medicine, Beograd, and High Military Technical School, Zagreb
M. Orlov ; Department of Pharmacology, Faculty of Medicine, Beograd, and High Military Technical School, Zagreb
D. Rakin ; Department of Pharmacology, Faculty of Medicine, Beograd, and High Military Technical School, Zagreb
M. Terzić ; Department of Pharmacology, Faculty of Medicine, Beograd, and High Military Technical School, Zagreb
B. Vasić ; Department of Pharmacology, Faculty of Medicine, Beograd, and High Military Technical School, Zagreb

Abstract

1,3 acetone bis (4-hydroxyimininoformyl pyridinium) dibromide (MBM-3) mp. 218-20° was synthetised from pyridine-4 aldoxime and 1,3 dibromacetone. The UV spectrum of MBM-3 dissolved in n/10 HCl has a maximum at 2820 A, and dissolved in n/10 NaOH at 3400 A. The IR spectrum indicates a syn-syn configuration. The LD50 of MBM-3 in white mice is 85 mg/kg (i. v.) and 155 mg/kg (i. p.). At 10-5 M concentration MBM-3 did not inhibit the erythrocyte cholinesterase itself but reactivated by 87% the erythrocyte cholinesterase inhibited with paraoxon, Applied together with atropine it offered in mice a complete protection against 80 LD50 of paraoxon.

Keywords

Hrčak ID:

177656

URI

https://hrcak.srce.hr/177656

Publication date:

28.6.1967.

Article data in other languages: croatian

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