Review article

Analysis of human chromosomes and ionizing radiation

Mira Tunkl ; Radioizotopni odjel Interne klinike Medicinskog fakulteta Sveučilišta, Zagreb
I. Šimonović ; Radioizotopni odjel Interne klinike Medicinskog fakulteta Sveučilišta, Zagreb

Abstract

Results obtained in the study of human chromosome lesions after exposure to various kinds of ionizing radiation are presented. It has been proved that radiation causes quantitative and qualitative changes in chromosomes. The frequency of these changes gradually decreases with time. In a number of cases, however, persistence of lesions has been proved years after radiation exposure. The occurrence of chromosome lesions after only one dose of radiation points at a possibility to determine the threshold of the radiation dose which brings about microscopically visible morphological changes in chromosomes. If this method proves valid for determining the correlation between the dosage and the frequency of chromosomal changes, then the chromosome analysis could serve as a biological dosimeter and a quantitative detector of changes occurring in the body at the cellular level. Owing to too small a number of authors' own results concerning the effects of various kinds of ionizing radiation upon human chromosomes data from literature are mostly reviewed.

Keywords

Hrčak ID:

177853

URI

https://hrcak.srce.hr/177853

Publication date:

21.3.1967.

Article data in other languages: croatian

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