Original scientific paper

Synthesis of Physiologically Active Steroid Esters and Spirolactones

Boris M. Seletsky ; Shemyakin Institute of Bioorganic Chemistry US SR Academy of Sciences, Moscow, USSR
George M. Segal ; Shemyakin Institute of Bioorganic Chemistry US SR Academy of Sciences, Moscow, USSR
Igor V. Torgov ; Shemyakin Institute of Bioorganic Chemistry US SR Academy of Sciences, Moscow, USSR

Abstract

Some steroid hemimalonates, alkylhemimalonates and acetoacetates
have been easily prepared in high yields by the reaction of hydroxysteroids with Meldrum acid, its alkyl- and acylderivatives,
respectively. Decarboxylation of the hemimalonates and alkylhemimalonates allowed the synthesis of several hydroxysteroid
esters, some of them being widely used in medical practice. 17a-hydroxyprogesterone hemimalonate and its acetoacetate, in the presence of bases, undergo cyc1odehydration giving rise to spirolactones which are potential aldosterone antagonists.

Keywords

Hrčak ID:

178056

URI

https://hrcak.srce.hr/178056

Publication date:

6.3.1986.

Visits: 823 *