Case report

IMPACT OF STRESS RESPONSE IN DEVELOPMENT OF FIRST-EPISODE PSYCHOSIS IN SCHIZOPHRENIA: AN OVERVIEW OF SYSTEMATIC REVIEWS

Linda Rossini Gajsak ; Neuropsychiatric Hospital Dr. Ivan Barbot, Popovaca, Croatia
Andrea Gelemanovic ; University of Split, School of Medicine, Split, Croatia
Martina Rojnic Kuzman ; Zagreb School of Medicine and University Hospital Center Zagreb, Zagreb, Croatia
Livia Puljak ; Laboratory for Pain Research, Cochrane Croatia, University of Split, School of Medicine, Split, Croatia

Abstract

Background: To summarize all available evidence from systematic reviews about the impact of stress response in development of
first-episode psychosis (FEP) in schizophrenia.
Methods: An overview of systematic reviews of any type of primary studies was performed. An electronic search of five
databases was conducted in February 2017 (CDSR, DARE, Embase, MEDLINE and PsychINFO). Quality of included systematic
reviews was assessed using the AMSTAR checklist.
Results: Eight systematic reviews were included. The main findings of the included reviews point out a possible alteration of the
stress response in a subgroup of persons with proneness to psychosis. However, the evidence is limited by the inadequate quality of
studies, as well as lack of standardization of outcomes and assessment methods.
Conclusions: Given the heterogeneity of current results, there is no solid evidence for uniform alterations of stress response
found in persons with FEP in suggestive of schizophrenia that may serve as a marker of vulnerability to stress and possibly
proneness to psychotic state in response to daily hassles.

Keywords

cortisol; hydrocortisone; stress; first-episode psychosis; schizophrenia

Hrčak ID:

178591

URI

https://hrcak.srce.hr/178591

Publication date:

20.3.2017.

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