Original scientific paper
Reactivation of phosphorylcholinesterase in the rat's cerebral cortex following parenteral application of pralidoxime (PAM - 2) and toxogonine
D. Anđewlković
; lnstitut z a farmahologiju i toksikologiju Medicinskog fakulteta, Beograd
M. Milošević
; lnstitut z a farmahologiju i toksikologiju Medicinskog fakulteta, Beograd
Abstract
From the recently proved selective affinity of pralidoxime (PAM-2) to certain areas of the brain it has been assumed that only .by measuring the enzymic activity of brain sections and not homogenates reactivation of the cholinesterase inhibited by organophosphorus compounds can be proved. A series of experiments performed on·paraoxone poisoned rats treated with pralidoxime and toxogonine (LüH 6) respectively showed a considerably higher cholinesterase activity in the cerebral cortex than in animals which received only the inhibitor. Contradictory results of various authors op. the reactivating property of pralidoxime in organophosphate poisoning are discussed and explained.
Keywords
Hrčak ID:
178652
URI
Publication date:
17.6.1966.
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