Original scientific paper
INFLAMMATORY BOWEL DISEASE AND KIDNEY– IS THERE A CONNECTION?
IVANA MIKOLAŠEVIĆ
; Rijeka University Hospital Center, Department of Nephrology, Dialysis and Kidney Transplantation, and Department of Gastroenterology, Rijeka, Croatia
SANDRA MILIĆ
; Rijeka University Hospital Center, Department of Gastroenterology, Rijeka, Croatia
BRANKICA MIJANDRUŠIĆ-SINČIĆ
; Rijeka University Hospital Center, Department of Gastroenterology, Rijeka, Croatia
VESNA LUKENDA ŽANKO
; Dr. Josip Benčević General Hospital, Department of Internal Medicine, Slavonski Brod, Croatia
ITA JELIĆ PRANJIĆ
; Rijeka University Hospital Center, Department of Nephrology, Dialysis and Kidney Transplantation, Rijeka, Croatia
VOJKO MAVRINAC
; Rijeka University Hospital Center, Department of Gastroenterology, Rijeka, Croatia
IRENA KRZNARIĆ-ZRNIĆ
; Rijeka University Hospital Center, Department of Gastroenterology, Rijeka, Croatia
SANJIN RAČKI
; Rijeka University Hospital Center, Department of Nephrology, Dialysis and Kidney Transplantation, Rijeka, Croatia
DAVOR ŠTIMAC
; Rijeka University Hospital Center, Department of Gastroenterology, Rijeka, Croatia
LIDIJA ORLIĆ
; Rijeka University Hospital Center, Department of Nephrology, Dialysis and Kidney Transplantation, Rijeka, Croatia
Abstract
The aim of the present study was to investigate whether patients with inflammatory bowel disease (IBD) have some degree of renal involvement. Furthermore, we investigated whether this connection is related to active bowel disease. In this cross-sectional study, 50 patients diagnosed with IBD, mean age 47.1±16.5 years, were recruited from September 2012 to September 2013. The diagnosis of IBD was based on clinical history, endoscopic, histological and radiological findings. Disease activity was assessed using the UC activity indeks (UCAI) for ulcerative colitis (UC) and Crohn’s disease activity index (CDAI) for Crohn’s disease (CD). There were 38% of UC patients and 62% of CD patients. The prevalence of abnormal albuminuria in UC and CD patients was 21.1% and 29%, respectively. There was a high negative correlation between duration of bowel disease and 24-h albuminuria in UC patients, as well as a high correlation between albumin-creatinine ratio (ACR) and UCAI score in UC patients, but these correlations were not statistically significant, probably due to the small number of UC patients. On the other hand, estimated glomerular filtration rate (eGFR) showed negative correlation with disease activity in CD patients (r=-0.569; p=0.05), while there was no statistically significant correlation between active UC and eGFR (r=0.343; p=NS). In conclusion, abnormal albuminuria is quite frequent in patients with IBD. It seems that patients with IBD have some degree of glomerular damage, mainly those with CD. Collaborative, prospective studies conducted by gastroenterologists and nephrologists are needed to investigate this association.
Keywords
inflammatory bowel disease; extraintestinal manifestation; kidney
Hrčak ID:
180118
URI
Publication date:
6.4.2017.
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